听力损失是人类的重大健康问题和心理负担。小鼠模型提供了阐明参与潜在发育和病理生理机制的基因的可能性。为此，大规模的鼠标表型计划包括单基因敲除小鼠线的听觉表型。使用听觉脑干响应（ABR）程序，德国鼠标诊所和全球类似设施已经产生了大型均匀的突变体和野生型小鼠的ABR原料数据。在标准ABR分析过程中，听力阈值通过训练有素的工作人员从增加声压水平的信号曲线进行视觉评估。这是令人耗时的，并且容易被读者偏向，以及图形显示质量和规模。为了减少工作量并提高质量和再现性，我们开发并比较了两种方法，用于从平均ABR原始数据中实现自动听力阈值识别：一个受监督方法，涉及在人生成的标签和自我监督方法上训练的两个组合神经网络，利用信号功率谱利用信号功率谱并将随机森林声级估计与转换曲线拟合算法结合起来进行阈值查找。我们表明，两种型号都很好地，胜过人类阈值检测，并且适用于快速，可靠和无偏见的听力阈值检测和质量控制。在高通量鼠标表型环境中，两种方法都以自动端到端筛选管道的一部分表现良好，以检测用于听力参与的候选基因。两种模型的代码以及用于此工作的数据都可以自由使用。

In intensively managed forests in Europe, where forests are divided into stands of small size and may show heterogeneity within stands, a high spatial resolution (10 - 20 meters) is arguably needed to capture the differences in canopy height. In this work, we developed a deep learning model based on multi-stream remote sensing measurements to create a high-resolution canopy height map over the "Landes de Gascogne" forest in France, a large maritime pine plantation of 13,000 km$^2$ with flat terrain and intensive management. This area is characterized by even-aged and mono-specific stands, of a typical length of a few hundred meters, harvested every 35 to 50 years. Our deep learning U-Net model uses multi-band images from Sentinel-1 and Sentinel-2 with composite time averages as input to predict tree height derived from GEDI waveforms. The evaluation is performed with external validation data from forest inventory plots and a stereo 3D reconstruction model based on Skysat imagery available at specific locations. We trained seven different U-net models based on a combination of Sentinel-1 and Sentinel-2 bands to evaluate the importance of each instrument in the dominant height retrieval. The model outputs allow us to generate a 10 m resolution canopy height map of the whole "Landes de Gascogne" forest area for 2020 with a mean absolute error of 2.02 m on the Test dataset. The best predictions were obtained using all available satellite layers from Sentinel-1 and Sentinel-2 but using only one satellite source also provided good predictions. For all validation datasets in coniferous forests, our model showed better metrics than previous canopy height models available in the same region.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

This paper presents the development of a system able to estimate the 2D relative position of nodes in a wireless network, based on distance measurements between the nodes. The system uses ultra wide band ranging technology and the Bluetooth Low Energy protocol to acquire data. Furthermore, a nonlinear least squares problem is formulated and solved numerically for estimating the relative positions of the nodes. The localization performance of the system is validated by experimental tests, demonstrating the capability of measuring the relative position of a network comprised of 4 nodes with an accuracy of the order of 3 cm and an update rate of 10 Hz. This shows the feasibility of applying the proposed system for multi-robot cooperative localization and formation control scenarios.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Machine-Learned Likelihoods (MLL) is a method that, by combining modern machine-learning classification techniques with likelihood-based inference tests, allows to estimate the experimental sensitivity of high-dimensional data sets. We extend the MLL method by including the exclusion hypothesis tests and show that the addition of Kernel Density Estimators avoids the need to bin the classifier output in order to extract the resulting one-dimensional signal and background probability density functions. We first test our method on toy models generated with multivariate Gaussian distributions, where the true probability distribution functions are known. We then apply it to a case of interest in the search for new physics at the HL-LHC, in which a $Z^\prime$ boson decays into lepton pairs, comparing the performance of our method for estimating 95\% CL exclusion limits to the results obtained applying a binned likelihood to the machine-learning classifier output.

社会机器人的快速发展刺激了人类运动建模，解释和预测，主动碰撞，人类机器人相互作用和共享空间中共同损害的积极研究。现代方法的目标需要高质量的数据集进行培训和评估。但是，大多数可用数据集都遭受了不准确的跟踪数据或跟踪人员的不自然的脚本行为。本文试图通过在语义丰富的环境中提供运动捕获，眼睛凝视跟踪器和板载机器人传感器的高质量跟踪信息来填补这一空白。为了诱导记录参与者的自然行为，我们利用了松散的脚本化任务分配，这使参与者以自然而有目的的方式导航到动态的实验室环境。本文介绍的运动数据集设置了高质量的标准，因为使用语义信息可以增强现实和准确的数据，从而使新算法的开发不仅依赖于跟踪信息，而且还依赖于移动代理的上下文提示，还依赖于跟踪信息。静态和动态环境。

TensorFlow GNN（TF-GNN）是张量曲线的图形神经网络的可扩展库。它是从自下而上设计的，以支持当今信息生态系统中发生的丰富的异质图数据。Google的许多生产模型都使用TF-GNN，最近已作为开源项目发布。在本文中，我们描述了TF-GNN数据模型，其KERAS建模API以及相关功能，例如图形采样，分布式训练和加速器支持。

语言模型既展示了定量的改进，又展示了新的定性功能，随着规模的增加。尽管它们具有潜在的变革性影响，但这些新能力的特征却很差。为了为未来的研究提供信息，为破坏性的新模型能力做准备，并改善社会有害的效果，至关重要的是，我们必须了解目前和近乎未来的能力和语言模型的局限性。为了应对这一挑战，我们介绍了超越模仿游戏基准（Big Bench）。 Big Bench目前由204个任务组成，由132家机构的442位作者贡献。任务主题是多样的，从语言学，儿童发展，数学，常识性推理，生物学，物理学，社会偏见，软件开发等等。 Big-Bench专注于被认为超出当前语言模型的功能的任务。我们评估了OpenAI的GPT型号，Google内部密集变压器体系结构和大型基础上的开关稀疏变压器的行为，跨越了数百万到数十亿个参数。此外，一个人类专家评估者团队执行了所有任务，以提供强大的基准。研究结果包括：模型性能和校准都随规模改善，但绝对的术语（以及与评估者的性能相比）；在模型类中的性能非常相似，尽管带有稀疏性。逐渐和预测的任务通常涉及大量知识或记忆成分，而在临界规模上表现出“突破性”行为的任务通常涉及多个步骤或组成部分或脆性指标；社交偏见通常会随着含糊不清的环境而随着规模而增加，但这可以通过提示来改善。

文本的结构化和接地表示通常是通过封闭信息提取形式化的，提取与从知识库模式的预定义实体集合和关系一致的穷举集（主题，关系，对象）三元组的问题。大多数现有的作品是管道容易出错的累积，所有方法都仅适用于不切实际的少数实体和关系。我们介绍了Genie（生成信息提取），第一端到最终的归属化闭合信息提取。 Genie自然地通过自动生成文本形式的关系和实体来利用预先训练的变压器的语言知识。由于新的双层约束生成策略，仅生产与预定义知识库模式一致的三胞胎。我们的实验表明，Genie在封闭信息提取时是最先进的，从较少的训练数据点广泛地推广到基线，并缩放到以前无管理数量的实体和关系。通过这项工作，封闭的信息提取在现实情景中变得实用，为下游任务提供了新的机会。最后，这项工作为信息提取的核心任务铺平了统一的端到端方法。在https://github.com/epfl-dlab/genie提供的代码和模型。